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More Parabolin (Parabolan) Alpha Pharma Information
Parabolin (Trenbolone 75mg) Box of 5 Ampoules – 1.5ml
- (Trenbolone Base + HexaHydroBencyl Carbonate Ester)
- Formula: C20 H24 O3
- Molecular Weight (base): 270.3706
- Molecular Weight (ester):130.1864
- Formula (base): C18 H22 O2
- Melting Point (base): 183-186C
- Manufacturer: (originally) Negma, Various Underground Labs
- Effective Dose (Men): 300-500mgs/week
- Effective Dose (Women): Not recommended
- Active life: 10-14 days
- Half-Life: 5-7 days
- Detection Time: 4-5 weeks
- Anabolic/Androgenic ratio: 500/500
Parabolan is used only by experienced users because it is a very powerful and tough product. Its main effect is to produce harder, denser, and stronger muscles, making it a very popular product for athletes.
Parabolan is neither affected by aromatase or 5-alpha-reductase. This means it becomes neither weaker nor stronger in androgen responsive target tissues and is a trait usually shared by DHT (DyhydroTestosterone) derived steroids. Since Parabolan is, of course, a Trenbolone, it is not actually DHT derived but rather, it is derived from 19-Nor-Testosterone. Parabolan has no estrogenic activity (it may actually reduce serum estradiol levels in the body), is a very strong anabolic and androgenic compound (5x stronger than testosterone in both categories!), and it binds well to the androgen receptor. Actually, binding “well” to the androgen receptor is quite an understatement. There is no injectable AAS in our arsenal that binds to the androgen receptor (AR) as well as Trenbolone does. This is probably a major reason that Parabolan was so sought after for use as a precontest agent. Androgen Receptors are found in fat cells as well as muscle cells, (8) and we all know that androgens act on the AR in muscle cells to promote growth. Androgens also act directly on the AR in fat cells to affect fat burning.(9)(6) The stronger the androgen binds to the A.R, the higher the lipolytic (fat burning) effect on the adipose (fat) tissue (9)(5). As if that’s not enough good news, some steroids even increase the numbers of A.R. in muscle and fat (9)(10), leading me to speculate that this fat losing effect would be amplified with the concurrent use of other compounds, such as injectable testosterone.
Another mechanism whereby Parabolan causes muscle accumulation and fat loss is its ability as a nutrient partitioning agent.(7) Basically, what this means is that while using Tren, more of the food you eat will become Muscle and less (if any) will become Fat. Really! As you can see, most of Parabolan’s cult reputation is well deserved. And as if that’s not enough, Parabolan noticeably increases the level of IGF-1 within muscle tissue (2), which in itself is an extremely anabolic hormone. And, it’s worth noting that not only does it increase the levels of IGF-1 in muscle over two fold (2), it also causes muscle satellite cells (cells that repair damaged muscle) to be more sensitive to IGF-1 and other growth factors(3). This leads me to speculate that Parabolan (or any version of Tren) would be synergistic within a cycle containing any form of injectable IGF-1.
Parabolan also happens to bind quite strongly to the glucocorticoid receptor as well, and this, in turn, imparts a nice anti-catabolic effect. This in part, may help to explain why low(ish) doses of it seem to work nicely, as well as why it aids fat loss. You see, glucocorticoid hormones send a message to muscle cells to release stored protein (this is called catabolism), which is exactly the opposite of what we want.
This drug stacks well with most everything especially Testosterone (actually, if you want to avoid sexual dysfunction, stacking it with testosterone is necessary). I have also found it to be a great addition to a stack containing Equipoise as well. Unfortunately, insomnia that Parabolan gives many users, added to the appetite increase the Equipoise can cause makes midnight snacking almost inevitable for those receiving these effects. Parabolan is most often used in cutting stacks when “quality muscle” gain is favored over bloat and water retention. Really, I think Parabolan (or any Tren) is a great “cutting” anabolic, although it has been used successfully by many in both Cutting and Bulking cycles.
Parabolan Side Effects
Some users of Para report sexual Dysfunction (Tren-Dick) and symptoms of Gyno (probably progesterone related, as Trenbolone acts on progesterone receptor but not the estrogen receptor). As you know, Trenbolone is, unfortunately, a progestin. Tren binds to the receptor of the female sex hormone progesterone (with about 60% of the actual strength of progesterone) (4). In hyper-sensitive muscle-research.com members, this can lead to bloat and breast growth when combined with an estrogenic or aromatizable product, but probably not when used without one (12). Worse still, Trenbolone’s active metabolite (17beta-trenbolone) has a binding affinity to the progesterone receptor that is actually greater than progesterone itself (5). No need to panic, though, the aromatase inhibitor Letrozole can also lower progesterone levels, and combat any progestogenic sides (13)(14). I would strongly consider its inclusion at .25-.5mgs/day in a cycle containing Parabolan or any 19-nor compound.
Ironically, even though Para is an excellent cutting drug, it will lower your thyroid level (11). Doing this, by means of the body’s negative-feedback-loop, also raises prolactin. Ergo, I recommend taking T3 (25mcg/day), or T4 (100mcg/day) along with your Tren to avoid suffering from increased levels of prolactin and the host of unwanted side effects this could cause. For these reasons, many people avoid stacking Tren with Deca (Nandrolone Decanoate), which is also a progestin (4).
Mental changes are a notorious side effect of any type of trenbolone use, and Para is no exception to this rule. Androgens increase chemicals in the brain that promote aggressive behavior(12). This can be beneficial for some athletes wanting to improve speed and power, but perhaps detrimental to those trying to hold a job as a social worker. I believe this can be controlled. It seems that if you are a laid-back, mild-mannered guy, you will still generally be that same way. If you are already an asshole, you will probably be an even bigger asshole.
For some, the worst effect of any sort of Trenbolone is “Tren cough”. Tren Enanthate does not have this effect on most, but Parabolan sometimes does. Tren Acetate seems to be the worst offender when it comes to Tren-Cough. Many do report that this side effect goes away after the first couple weeks of use. Also, any kind of Tren gives many users a bit of insomnia. The most noticeable side effect of Parabolan generally is that it increases sweating dramatically, even giving users vicious “night sweats” that go nicely with insomnia. Walking up a flight of stairs can cause some Tren users to break out in beads of sweat and become winded. Having mentioned that, it needs to be noted that many people experience a reduced cardiovascular capacity when using Para. Still, its incredible effects on strength and appearance mean that it will fall into many members’ cycles for off seasons and in the winter (when sweating won’t be as much of a problem).
- Br J Nutr. 1978 Nov;40(3):563-72.
- J Cell Physiol. 2004 Nov;201(2):181-9.
- Endocrinology. 1989 May;124(5):2110-7.
- Cancer Res 1978 Nov; 38(11 Pt 2):4186-98
- APMIS. 2000 Dec;108(12):838-46.
- (Xu X, et al. “The effects of androgens on the regulation of lipolysis in adipose precursor cells.” Endocrinology 1990 Feb;126(2):1229 ).
- J Anim Sci. 1992 Nov;70(11):3381-90.
- Am J Physiol. 1998 Jun;274(6 Pt 1):C1645-52.
- Biochim Biophys Acta. 1995 May 11;1244(1):117-20.
- J Appl. Physiol.94 1153-61 2003
- Res Vet Sci 1981 Jan;30(1):7-13
- Med Sci Sports Exerc. 2003 Jan; 35(1):32-8
- Progesterone is not essential to the differentiative potential of mammary epithelium in the male mouse. Freeman, Topper. Endocrinology. 1978 Jul;103(1):186-92
- Eur J Obstet Gynecol Reprod Biol. 2002 Nov 15;105(2):161-5.
- J Clin Endocrinol Metab. 1995 Sep;80(9):2658-60.