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Clomiphene citrate activates the natural biofeedback mechanism in the brain. This activates the secretion of the body’s follicle-stimulating hormones (FSH) such as glycoprotein.

Clomid, or Clomiphene Citrate, is a SERM (selective estrogen receptor modulator), so it’s in the same grouping as tamoxifen (nolvadex). It is the most widely prescribed drug for ovulation induction, which is useful for those who are infertile. Studies have shown a pregnancy rate of 5.6% per cycle with clomid treatment vs 1.3% without. This makes clomid an inexpensive and excellent fertility drug for females.

Historically, clomid has been used since the 1960’s to help females with infrequent menstruation. Thereafter, its use expanded to include fertility issues in females. In 1989, a patent was awarded to Yale University medical researchers to predict fertility in women with the help of clomiphene citrate.

What is Clomiphene Citrate (Clomid)?

Male bodybuilders who cycle anabolic androgenic steroids (AAS) have found that the same mechanisms of increased LH (luteinizing hormone) can be taken advantage of to increase total testosterone levels. This is why clomid is popular in post cycle therapy (PCT) among those who cycle anabolic steroids. Since clomid has ability to bind to the estrogen receptors, much like nolvadex, in male users who run estrogenic compounds such as testosterone, dianabol, and deca durabolin, it can be used as gynecomastia treatment (anti-gyno). However, clomid is a fairly weak anti-gyno aid, and is rarely used for that purpose. Due to its ability to boost testosterone levels, it has been put on the WADA (world anti-doping agency) list of illegal doping agents in sport.

Clomiphene Citrate and Post Cycle Therapy (PCT)

When a steroid user runs a cycle their HPTA becomes suppressed; as a result, their bodies LH and FSH drop to almost zero (0) and their body stops producing testosterone. Their testicles typically will shrink as the body realizes there are too many hormones present and it’s not necessary to produce more. So, when you come off a cycle it’s important to run a PCT (post cycle therapy) to help recover the body’s HPTA.

Unlike HCG (Human Chorionic Gonadotropin), clomid does NOT mimic LH in the body. As a result, it does not cause testosterone to rise, thus suppressing LH and FSH levels in the body. This is why clomid makes sense to use in pct and hcg does NOT. So how does it work?

Clomid stimulates the hypophysis to release more gonadotropins. Gonadotropins are protein hormones that are secreted by gonadotrope cells of the pituitary gland and stimulate faster and higher release of follicle stimulating hormone (FSH) and luteinizing hormone (LH). When an increase in gonadotropins happens, the rise in LH will spike up the total testosterone levels allowing the user to artificially maintain high testosterone levels until their own body is able to recover, thus maintaining gains.

More about Clomid

Clomiphene citrate thus provides for an increase in the follicle stimulating hormone and the luteinizing hormone (LH), which leads to follicular maturation and triggering of ovulation in women.

In men, the luteinizing hormone stimulates the testes between the testes and regulates the androgen biosynthesis of the testis. This effect is particularly beneficial for the bodybuilder at the end of a steroid cure, when the endogenous testosterone production is below average.

If without the addition of synthetic testosterone, the testosterone levels would drop far below normal, the bodybuilder would lose mass and strength very quickly.

The release of the luteinizing hormone from the anterior and middle parts of the pituitary front lobe is controlled by the LH releasing hormone or factor from the hypothalamus.

Clomiphene gradually increases the testosterone level over the period of administration. It also appears to be effective as an anti-estrogen. Most bodybuilders suffer from “aromatization” of steroids under an elevated estrogen level at the end of a cure.

A high estrogen level in association with a low testosterone level increases the risk of developing gynecomastia. The use of clomiphen can be counteracted.

Side effects:

Allergic reactions like skin rash, itching or hives, drowsiness, dizziness, fainting, thrush, numbness, weakness or somnolence

Application / dosage:

The following dosage is known as a common pattern over a period of 4 weeks in bodybuilder circles: 1st week 100mg / day – 2nd week 50mg / day – 3rd week 25mg / day – 4th week 25mg / day

The dosage information given here is not intended as a dosage recommendation or medical advice. These are statements by bodybuilders who have used or used these active ingredients. The dosages should never be regarded as generally valid. If you are using the idea of using steroids or similar, ask a doctor or pharmacist.